锰对工人血清胆碱酯酶活性和尿香草扁桃酸含量的影响

Effect of Manganese on Activity of Cholinesterase in Serum and Concentration of Vanillymandelic Acid in Urine among the Exposed Workers

为探讨职业性锰暴露对工人血清胆碱酯酶活性和尿香草扁桃酸 (VMA)水平的影响 ,对 5 5名锰粉加工工人、5 5名冶炼工人和 5 5名对照工人进行了调查。结果显示 ,锰粉加工作业环境空气锰尘中MnO2 几何均数为 1 96mg m3 (0 17～ 2 2 2 4mg m3 ) ,样品超标率为 88 9% ;冶炼作业环境空气锰烟尘中MnO2 几何均值为 0 6 5mg m3 (0 0 6～ 6 6 7mg m3 ) ,样品超标率为 93 3%。锰粉加工和冶炼组头晕头痛、睡眠障碍的主诉率明显高于对照组 (P <0 0 1) ,锰粉加工组血清胆碱酯酶活性明显增高 (P <0 0 5 ) ,提示这可能是锰的早期神经毒性所致。

To approach the effect of occupational manganese exposure on serum cholinesterase (ChE) and urinary vanillymandelic acid (VMA), the subjective symptoms, serum ChE activity and urinary VMA concentration were examined in 55 milling workers, 55 smelting workers and 55 control subjects. The result showed that geometric mean of MnO\-2 concentration in the air manganese dust of the milling workplace was 1\^96 mg/m\+3 and ranged from 0\^17 to 22\^24 mg/m\+3, the exceeding rate was 88\^9% from a total number of 9 samples in 5 worksites. The geometric mean of MnO\-2 concentration in the air manganese smoke of the smelting workplace was 0\^65 mg/m\+3 and ranged from 0\^06 to 6\^67 mg/m\+3, the exceeding rate was 93\^3% from a total number of 13 samples in 5 worksites. The milling workers, together with higher prevalence of subjective neurological disturbances such as dizziness and headache, insomnia, showed a significant increase in the activity of serum ChE than that of the controls, suggesting that may be caused by early manganese neurotoxicity.