注射用两性霉素B胆固醇酰硫酸钠治疗30例深部真菌感染

Clinical evaluation of intravenous amphoterin B colloidal dispersion for the treatment of 30 patients with invasive fungal infections

目的 :评价进口注射用两性霉素B胆固醇酰硫酸钠 (ABCD)治疗深部真菌感染的疗效和安全性。方法∶以本药 (成人每日 2 .5～ 3.5mg/kg)非对照开放试验治疗下呼吸道真菌感染、隐球菌脑膜炎、败血症等深部真菌感染 30例。其中隐球菌性脑膜炎及肺炎的部分患者联合应用氟胞嘧啶。结果∶痊愈 15例、显效 14例、无效 1例 ,有效率 96 .7%、痊愈率 5 0 % ,真菌培养阴转率 96 .8% ,涂片阴转率 93.5 %。作安全性评价的 34例中 ,出现不良反应者 2 4例、33例次 ,实验室异常者 18例、2 3例次 ,2例因不良反应中止治疗。结论∶注射用ABCD治疗念珠菌属、隐球菌属等真菌性下呼吸道感染、脑膜炎、败血症等深部真菌感染疗效确切 ,不良反应并非少见 ,但多数程度较轻 。

Objective: To evaluate the efficacy and safety of amphoterin B colloidal dispersion (ABCD) for the treatment of invasive fungal infections.Methods:A total of 30 patients with respiratory tract infections, cryptococcus meningitis and septicemia caused by fungi infections were treated with ABCD (adult 2.5-3 mg·kg -1 d -1 ) in an open calinical study. Results:15 patients were cure, 14 patients marked improve, 1 failed. The total clinical efficacy rate of ABCD was 96.7%, with cure rate of 50%. The fungi eradication rate of fung culture were 96.8%, eradication rate of fungus smar were 93.5%. Of the 34 safety evaluable patients, 33 adverse events occured in 24 patients, 23 events abnormal laboratory tests occured in 18 patients. Two patients discontiued treatment due to adverse reaction. Conclusions: Intravenous ABCD was effective in treating respiratory tract infection, meningitis and sepiticemia caused by candida, cryptococcus, et al. The adverse reactions were commen but most were mild and tolerable.