1998—2000年深圳医院细菌耐药性监测

Surveillance of bacterial resistance in Shenzhen hospital in 1998-2000

目的 :监测 1998— 2 0 0 0年本院常见致病菌对抗菌药物的耐药性。方法∶Kirby Bauer琼脂扩散法测定 6 82株革兰阴性菌和 390株革兰阳性菌对 2 0种抗菌药物的敏感性。结果∶多数革兰阴性菌对头孢哌酮、头孢曲松和头孢噻肟耐药率明显增加 ,大肠埃希菌对环丙沙星耐药率高达 6 3.5 %。 2 8.6 %金黄色葡萄球菌和 5 8.4%凝固酶阴性葡萄球菌为甲氧西林耐药株 ,但对万古霉素均敏感。 3.4%肠球菌对万古霉素耐药。大肠埃希菌和肺炎克雷伯菌产超广谱 β内酰胺酶 (ESBLs)阳性率分别是34 .0 %和 2 9.6 %。结论∶本地区常见致病菌耐药情况较严重 ,需合理使用和控制滥用抗生素。

Objective: To investigate the resistance of clinical bacterial isolates in the hospital. Methods:Using Kirby Bauer method for bacterial susceptibility testing, twenty different antibiotic discs were used. Results:Among 1 072 isolates 682(63.4%) were Gram(-) bacilli,390(36.6%)Gram(+) cocci.34.0% E. coli and 29.6% strains of Klebsiella spp produced β lactamase(ESBL).28.6% Staphalcocci aureus and 58.4%coagulase negative stapyalococci were resistant to oxacillin, but no vancomycin resistant strain was found. Vancomycin resistant strains of Enterococci were about 3.4%.Most strains of Enterobaceriaceae were resistant to ampicillin. Resistant rates of Gram(-) bacilli against cefperazone, ceftriaxone and cefotaxime increased markedly .Imipenem had high activity for most strains of Gram(-) bacilli. Conclusions: The severe situation of antibiotic resistance caus for restrictied of misuse of antibiotics.