饮水中低亚硝酸盐、硝酸盐含量加入二级胺诱发大鼠前胃乳头状瘤

The further study on the inducement of papilloma of the forestomach in rats by the giving water containing low amount of nitrite and nitrate plus second amnes

用wistar大鼠158只分为6组进行诱癌实验。结果:饮水中硝酸盐氮含量、亚硝酸盐氮含含量均低于卫生标准上限量的情况下,加入二级胺仍有致瘤作用。营养低下可促进癌前病变的发生。

In this experment, 158 male and female wistar rats were divided into 6 groups.In group 1, 2, and 3, the animals were given the same drinking water containing 0.5 mg% sodium nitrite,270 mg% sodium nitrate and 20mg% sarcosine ethylester hydrochloride. In group 1, the animals were fed with common feed, in group 2,corn-flour, and in group 3, corn-flour for the first two months. then common feed.In group 4, the animals were given the drinking water containing 0.1mg% sodium nitrite, 54 mg% sodium nitrate and 20 mg% sarcos ine-ethyester hydrochloride with corn-flour as feed. In group 5, the animals were given distilled water with corn-flour as feed. In group 6, the animals were given distilled water and common feed. The hyperplastic and precancerous lesions of varying degrees were found in the epithelium of the forestomach of the rats in all the groups except group 5 and 6. The expermental results indicate that drinking water containing lower amount of nitrogen of nitrite and nitrate than that of health standard critical value still possesses tomorigenicity, if second amines were added to it, and that undernutrition may promote the generation of the precancerous lesions.