SLE患者的白细胞介素2受体(IL—2R)在免疫病理机制上的研究——Ⅰ.SLE患者外周血淋巴细胞膜上IL—2R表达能力的分析

Study of IL—2R on the Immunopathologic Mechanism in Patients with SLE I.Analysis of the Expression of IL—2R on Lymphocytes from Patients with SLE

本实验用Wu Tac单抗的间接荧光抗体法检测了14例系统性红斑狼疮(SLE)患者淋巴细胞膜上IL—2R 的表达,其中13例处于疾病活动期,1例为缓解期。所得结果与16例正常人的Tac^+细胞(45.69±3.42%)相比,发现SLE 患者淋巴细胞的IL—2R 表达能力明显下降,Tac^+细胞仅为19.29±3.24%。此结果将有助于进一步探讨SLE 的免疫调节紊乱的发生机制。

By indirect fluorescent antibody techniques(IFAT),we studied the expression of IL—2 R in(?)4 patients with SLE(13 had active disease and 1 was in remission).Compared with those ob-ained in 16 healthy subjects,we found that the expression of 1L—2R in the patients with SLE ob-viously decreased.Our results may contribute may contribute to the study on the immunoregulato-ry aberration of SLE.