血敏宁颗粒治疗上消化道出血的药效学实验研究

Pharmacodynamics of Xueminning Granule on hemorrhage of upper digestive tract

目的 :观察血敏宁颗粒治疗上消化道出血的药理作用。方法 :采用大鼠幽门结扎型溃疡模型 ,无水乙醇致大鼠胃粘膜损伤模型 ,利血平致小鼠胃溃疡模型观察本品对实验性胃溃疡的影响 ;通过分析大鼠胃液 ,观察本品对大鼠胃液分泌的影响 ;采用毛细玻管法及断尾法分别测定本品对小鼠凝血时间和出血时间的影响 ;并测试本品对小鼠血小板计数的影响。结果 :血敏宁颗粒对上述 3种胃溃疡模型均具有明显的作用 ,给药组溃疡指数明显降低 ;胃液排出量明显减少 ;小鼠凝血时间和出血时间明显缩短。结论 :血敏宁颗粒具有治疗上消化道出血的药理学基础。

Objective: To observe the pharmacodynamics of Xueminning Granule (XG) on hemorrhage of upper digestive tract.Methods:Applying pylorus-ligated stomach ulcer model on rats; gastric mucosa injury induced by absolute ethy1 alcohol on rats and stomach ulcer induced by reserpine on mice to investigate the stomach ulcer-preventive effects of XG; applying the gastric juice analysis to investigate the mechanism of XG;applying the coagulation time test and bleeding time test and platelet count on mice to investigate the hemostatic effects of XG. Results: obviously prophylactico-therapeutic effects on three stomach ulcer model were found; the ulcer index and gastric juice output were decreased; the coagulation time and bleeding time were shortened.Conclusion:pharmacodynamics basis of XG on hemorrhage of upper digestive tract were provided.