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中草药核糖体灭活蛋白在生物医学中的应用 被引量：1

Application of ribosome-inactivating proteins of Chinese herbs in biomedicine
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摘要 核糖体灭活蛋白广泛存在于中草药中 ,本文主要综述了核糖体灭活蛋白的分布、分类和性质、毒性机制。
作者 甘永华 李豫川 先宏
机构地区 军事医学科学院微生物流行病研究所
出处 《中草药》 CAS CSCD 北大核心 2002年第4期374-377,共4页 Chinese Traditional and Herbal Drugs
关键词 生物医学 应用 核糖体灭活蛋白 中草药 ribosome inactivating proteins Chinese herbs application in medicine
分类号 R282.71 [医药卫生—中药学] R318 [医药卫生—生物医学工程]
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参考文献18

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  • 2[2]Chow L P, Chou M H, Ho C Y, et al. Purification, characterization and molecular cloning of trichoanguin, a novel type I ribosome-inactivating protein from the seeds of Trichosanthes anguina[J]. Biochem J, 1999, 338(1):211-219.
  • 3[3]Chen R, Xu Y Z, Wu J, et al. Purification and characteriza tion of trichomaglin-a novel ribosome-inactivating protein with abortifacient activity[J]. Biochem Mol Biol Int. 1999, 47(2) : 185-193.
  • 4[4]Terawaki K, Nose M, Kondo T, et al. Effect of karasurin-A on nitric oxide production by murine macrophages and mito genic response of murine splenocytes in vitro[J]. Biol Pharm Bull, 1997, 20(4):435-437.
  • 5[5]Chen M, Ye X, Cai J, et al. Crystallization and preliminary crystallographic study of cucurmosin, a ribosome-inactivating protein from the sarcocarp of Cucurbita moschata[J]. Acta Crystallogr D Biol Crystallogr, 2000, 56(5): 665-666.
  • 6[6]Hirao I, Madin K, Endo Y, et al. RNA aptamers that bind to and inhibit the ribosome-inactivating protein, pepocin[J]. J Biol Chem, 2000, 275(7) :4943-4948.
  • 7[7]Wu T H, Chow L P, Lin J Y. Sechiumin, a ribosome-inactivating protein from the edible gourd, Sechium edule Swartzpurification, characterization, molecular cloning and expression[J]. Eur JBiochem, 1998, 255(2): 400-408.
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同被引文献49

  • 1郑硕,李格娥.抗癌活性成分——核糖体失活蛋白在植物界的分布[J].中草药,1993,24(6):327-329. 被引量：4
  • 2许梅芬.天花粉蛋白抗旱孕[J].实用妇产科杂志,1994,10(1):9-10. 被引量：10
  • 3李霖,王文学,邹伯英.蓖麻毒素修饰物的制备和细胞毒作用[J].第四军医大学学报,1996,17(3):178-180. 被引量：8
  • 4董巨莹,王文学,王剑波.蓖麻毒素诱导小鼠肝脏产生肿瘤坏死因子[J].第四军医大学学报,1997,18(1):78-78. 被引量：8
  • 5Barbieri L,Battelli MG,Stirpe F.Ribosome-inactivating proteins from plants.Biochim Biophys Acta,1993,1154:237-282.
  • 6Endo Y,Wool IG.The site of action of alpha-sarein on eukaryotic ribosomes:The sequence at the alpha-sarcin cleavage site in 28S ribosomal ribonucleic acid.Journal of Biological Chemistry,1982,257:9054-9060.
  • 7Endo Y,Tsurugi K.RNA N-glycosidase activity of ricin Achain:mechanism of action of the toxic lectin riein on eukaryotic ribosomes.Journal of Biological Chemistry,1987,262:8128-8130.
  • 8Endo Y,Mitsui K,Motizuki M,et al.The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes:the site and the characteristics of the modification in 28S ribosomal RNA caused by the toxins.Journal of Biological Chemistry,1987,262:5908-5912.
  • 9Stirpe F,Olsnes S,Pihl A.Gelonin,a new inhibitor of protein synthesis,nontoxic to intact cells.Isolation,characterization and preparation of cytotoxic complexes with concanavalin A.Journal of Biological Chemistry,1980,255:6947-6953.
  • 10Fiorenzo S.Ribosome-inactivating proteins (Review),Toxicon,2004,44,371 -383.

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中草药
2002年 第4期

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