尿FDP含量对膀胱肿瘤的临床诊断价值

Clinical value of urine FDP content for the diagnosis of bladder tumor

目的 :探讨尿液中纤维蛋白降解产物 (FDP)含量变化与膀胱肿瘤的关系及其作为肿瘤标记物的可能性和临床诊断价值。方法 :采用反向血凝试验法检测膀胱癌及其他良性泌尿生殖系疾病患者各 2 7例的晨尿尿液FDP的含量。结果 :膀胱癌患者尿液FDP含量为 39.37± 32 .70ml/L ,明显高于非膀胱癌者的 4.0 3± 3.2 3ml/L ,差异有显著性意义 (P <0 .0 1)。结论 :膀胱癌患者尿液中FDP含量增高与膀胱癌的表现有关 ,FDP可能是一种潜在的替代尿脱落细胞学检测膀胱移行细胞癌的肿瘤标记物。

Purpose:To investigate the diagnositc value of urine FDP content.Methods: The content of morning urine FDP was measured in 27 patients with bladder tumor and other benign urogenital diseases respectively by reverse hemaglutination test.Results: The urine FDP content in bladder tumor group was significantly higher ( 39.37 ± 32.70 ml/L) than that in other benign urogenital disease group ( 4.03 ± 3.23 ml/L) (P< 0.01 ).Conclusions: The raise of urine FDP content was associated with the behavior of bladder tumor, therefore the urine FDP content may be a potential bladder tumor marker and the measurement of urine FDP content would be an alternative test to urinary cytology for detection of bladder transitional carcinoma.