番泻叶浸剂对动物小肠运动和尿量的影响

Effects of Cassia Angustifolia Extract on Animal Small Intestine Movement and Urine Volume

目的:观察番泻叶浸剂对小鼠小肠运动和尿量的影响。方法:应用小肠推进试验法观察炭末在小肠的推进速度;用离体动物回肠实验,观察本品对离体回肠收缩幅度和频率的影响;用简式粪便尿分离代谢笼法观察本品对小鼠尿量的影响。结果:番泻叶浸剂对小鼠小肠炭末有明显推进作用(P<0.05);对大鼠和家兔离体肠肌收缩幅度有明显增强作用(P<0.05);灌服25％番泻叶浸剂后0.5,1h和灌服番泻叶浸剂原液后0.5,1.2h,尿量均有明显增加。结论:番泻叶浸剂能通过增加小肠蠕动和抑制水分吸收而发挥泻下作用,也可能具有利尿作用。

Objective: To study the effects of Cassia angustifolia extract (CAE) on animal small intestine movement and urine volume. Methods: Animal small intestine propelling speed was determined by surveying the moving rate of charcoal power, the amplitude and frequency of isolated ileum contraction were detected with two-channel physiological recorder, and the urine volume of mice was collected with sparated metabolic cages. Results: CAE could accelerate the propelling rate of charcoal powder in mice's small intestine , and increaing the contraction amplitude of rats' isolated ileum and that of rabbits (n = 10, P< 0.05). The urine volume in mice was increased 0.5 and 1 hour after ig of 25%CAE, and also 0.5,1,and 2 hours by ig of 100%CAE. Conclusion: CAE stimulates the peristalsis of small intestine, inhibiting absorption of water acting on purgation. It also possesses definite diuretic action.