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缺氧诱导因子-1与肿瘤 被引量:43

Hypoxia-inducible factor-1 and tumor
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出处 《中华病理学杂志》 CAS CSCD 北大核心 2002年第2期168-170,共3页 Chinese Journal of Pathology
基金 国家自然科学基金资助项目 ( 39870 30 5 )
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参考文献23

  • 1Semenza GL,Agani F,Booth G,et a1.Structural and f un ctional analysis of hypoxia-inducible factor 1.Kidney Int,1997,51:553-555.
  • 2Minet E,Michel G-Remacle P,et al.Role of HIF-1 as a tran scription factor i nvolved in embryonic development,cancer progression and apoptosis.Int J Mol Me d,2000,5:253-259.
  • 3Maxwell PH,Dachs GU,Gleadle JM,et a1.Hypoxia-inducible f actor 1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growt h. Pro Natl Acad Sci U S A,1997,94:8104-8109.
  • 4Boast K,Binley K,Iqbau S,et al.Characterization of physiologi cally regulated v ectors for the treatment of ischemic disease.Human Gene Therapy,1999,10:2197- 2208.
  • 5Okino ST,Chichester CH,Whitlock JP Jr.Hypoxia-inducible mamm alian gene express ion analyzed in vivo at a TATA-driven promoter and at initiator-driven promote r. J Biol Chem, 1998,273:23837-23843.
  • 6Ruan H,Wang J,Hu L,et al. Killing of brain tumor cells by hypoxia-responsive element mediated expression of BAX. Neoplasi a, 1999,1:431-437.
  • 7Suzuki H,Tomida A,Tsuruo T,et al.Dephosphorylated hypoxia-in ducib le factor 1 alpha as a mediator of p53-dependent apoptosis during hypoxia.Oncog e ne,2001,20:5779-5788.
  • 8Bl agosklonny MV,An WG,Romanova LY,et al.p53 inhibits hypoxia-inducible factor-s ti mulated transcription.J Biol Chem,1998,273:11995-11998.
  • 9Ravi R,Mookerjee B,Bh ujwalla ZM,et al.Regulation of tumor,or angiogenesis by p53-induced degradatio n o f hypoxia-inducible factor 1 alpha.Genes Dev,2000,14:34-44.
  • 10Jiang BH,Agani F,Pas saniti A,et al.V-SRC induces expression of hypoxia-inducible factor 1(HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1:involvement of HIF-1 in tumor progression.cancer Res, 1997,57:5328-5335.

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