CA_(125)对子宫内膜癌检测及临床意义

Serous CA_(125) levels and its clinical value in primary endometrial carcinoma.

目的 探讨血清CA12 5值对子宫内膜癌早期诊断、监测病情变化和预测预后的价值。方法 用免疫化学法检测 5 5例子宫内膜癌患者和 16例良性子宫病变患者血清CA12 5水平。结果 良性子宫病变和 4 4例手术分期为Ⅰ期的子宫内膜癌患者血清CA12 5阳性率分别为 19 4 %和 2 7 3% ,两者相比 ,P >0 0 5 ,无显著性差异 (P>0 0 5 )。手术分期为Ⅰ期和 10例晚期病人 (Ⅲ期 +Ⅳ期 )血清CA12 5的阳性率各为 2 7 3%和 70 % ,两者相比 ,有显著性差异 (P <0 0 5 )。 30例Ⅰa期 +Ⅰb期和 14例Ⅰc期病人血清CA12 5的阳性率分别为 2 0 %和 4 7 8% ,两者相比 ,无显著性差异 (P >0 0 5 )。病理分级中 30例G1、2 0例G2 、5例G3 血清CA12 5的阳性率分别为 2 0 %、4 5 %、80 % ,三者相比 ,相互之间有显著性差异 (P <0 0 5 )。结论 血清CA12 5的检测对早期诊断子宫内膜癌缺乏敏感性 ,对早期内膜癌患者预测手术分期 ,Ⅰc期无明显的参考价值 ,但与手术分期和病理分级密切相关 。

Objective To discuss the clinical value of serous CA 125 in early dignosis,monitoring the illness and prognosis of primary endometrial carcinoma.Methods Serous CA 125 levels were measured by immunochemistry in 55 cases of primary endometrial carcinoma and 16 cases of benign uterine lesion respectively.Results CA 125 positive levels were found in 3(19 4%) benign cases and 12(27 3%) endometrial carcinoma in operative stage Ⅰ.The differene was not statistically significant (P>0 05). CA 125 positive levels were found in 7(70%) operative stageⅢ～Ⅳ carcinoma,which was significantly different from that of stage Ⅰ(P<0 05).The CA 125 positive rate in 30 cases of Ⅰa+Ⅰb and 14 caes of Ⅰc was 20% and 47 8%,respectively,no significant difference(P>0 05).CA 125 positive rate in pathological grade G 1(30 cases),G 2(20 cases) and G 3(5 cases) was 20%,45% and 80% respectively,significant difference was found between any two of them(P<0 05).Conclusion Serous CA 125 is not sensitive to early endometrial carcinoma, but it is closely related with operative stage, pathological gradation,which may be of value in predicting the prognosis.