血浆脂质结合唾液酸变化对颅内肿瘤疗效判断的意义

Plasma lipid-bound sialic acid alterations for the prognosis of intracranial tumor

目的 :探讨血浆脂质结合唾液酸 (lipid boundsialicacid ,LSA)变化对颅内肿瘤疗效判断的意义。方法 :采用朱翔等改良硫代巴比妥酸比色法测定了 83例颅内肿瘤患者的血浆LSA ,并对其中 47例进行了术后 6～ 12个月的随访。结果 :良性肿瘤组于术后 1～ 3个月血浆LSA逐渐恢复至正常 ,而恶性胶质瘤患者 ,术后一个月LSA稍下降 ,经手术全切 ,一年内未复发者 12例 ,术后 6～ 12个月血浆LSA基本下降至正常水平 ;反之 ,经手术全切一年内复发者 12例 ,术后 6～ 12个月又升高 ,与术后一个月血浆LSA含量相比差异显著 (P <0 .0 1)。结论 :血浆LSA含量检测可作为颅内肿瘤的辅助诊断措施 。

Objective: To investigate the clinical implication of plasma lipid bound sialic acid(LSA) measurement for the diagnosis and prognosis of intracranial tumor.Methods: LSA in the plasma was determined by the thiobarbituric acid(TBA),which used for 83 cases of intracranial tumors and follow up 47 cases.Results: The plasma LSA level in the patients with benign tumor reached normal level within 1 to 6 months after surgery but in the patients with malignant glioma which the plasma LSA level was slightly decreased within one month after tumor resection,in 12 cases of patients with complete tumor resection and no tumor recurrences within one year,the plasma LSA level was steadily decreased thereafter,reaching normal level within 6 to 12 month after surgery,whereas in the 12 patients with tumor recurrences,the plasma LSA level was increased again within 6 months after tumor resection.Conclusion: Plasma LSA assay is a method for the diagnosis of intracranial tumor and is helpful for the prognosis of malignant glioma.