氯氮平对血清钾的影响121例临床观察

A Clinical Study of Inffluene of Clozapine on the Changes of Serum K^+ Level:A Report of 121 Cases.

目的 探讨氯氮平对血清钾的影响。方法 单一服用氯氮平的精神分裂症患者 30 8例观察 3个月 ,每周测定血清钾、心电图、简明精神病评定量表 ( BPRS)各 1次。结果 发生低血钾 1 2 1例 ,多发生在治疗第七周至第十周 ,部分患者出现低血钾症状 ,其中 2例因并发症死亡。结论 氯氮平对血清钾的影响临床应该给予足够的重视。

Objecitve The study was to investigate the inffluence of clozapine on the changes of serum K + level.Method 308 patients with schizophrenia were treated with clozapine for three months.All the patients were examined with ECG and the symptoms were assessed with the Brief Psychiatric Rating Scale(BPRS),The level of serum K + was also measured.All the tests were conducted once a week.Results 121 cases suffered fromed low serum K+ level,most of which occurred seven to ten weeks later.The symptoms of low serum K + appeared in some of these cases,among which two cases died from the complications.Conclusion The inffluence of clozopine on the level of serum K + was remarkable.It is more reasonable to pay attendion to this side effect.