原发性高血压和脑卒中患者胰岛素抵抗和脂代谢异常的初步研究

A study on the abnormalities of serum insulin and lipid metabolism in primary hypertension and stroke patients

目的 :研究原发性高血压和脑卒中患者体内胰岛素水平和脂代谢的异常。方法 :选取43名肝肾功能正常 ,体重指数<25kg/m2成年人 ,分成3组 :正常对照组15例 ,平均年龄 (61.40±5.95)岁 ;脑卒中组:15例,平均年龄(65.26±9.42)岁 ;高血压组:13例,平均年龄 (70.00±7.80)岁。所有各组进行糖耐量 ,胰岛素释放实验和血脂检测。结果 :患病组0.5h ,1h ,2h血糖和各点胰岛素水平显著高于正常对照组 ,总胆固醇 ,低密度脂蛋白 ,极低密度脂蛋白 ,载脂蛋白B和LP(α)较正常对照组显著增加。结论 :高胰岛素血症和高脂血症与脑卒中和原发性高血压的发生有较高联系 ,胰岛素和LP(α)升高是心脑血管病发生的危险因素。

Objective: To study the abnormalities of serum insulin and lipid metabolism in primary hypertension and stroke patients.Methods: Forty-three people with normal liver, kidney function and BMI<25kg/m2 were selected(control group: 15, 61.40±5.95 year old; primary hypertension:13 70.00±7.80 year old; stroke group: 15, 65.26±9.42 year old.OGTT,IRT and blood lipid test were carried out to each group.Results: In IGTT and IRT blood glucose at 0.5h 1h 2h and insulin level at all points in hypertension and stroke group were significantly increased than those of control group. TC,LDL-C,VLDL,APOB,LP(α)were also higher than those of control group.Conclusion:Hyperinsulineamia and hyperlipidemia are high risk factors of stroke and hypertension.