胸腺放射治疗重症肌无力的疗效观察

Therapeutic effect analysis on thymus radiotherapy of myasthenia gravis

目的 观察胸腺放射治疗重症肌无力 (MG)的疗效。方法 回顾性分析我院自 195 7年到 1999年 4 2年间应用胸腺放射治疗的 6 8例 MG患者 (深部 X线放疗 2 2例 ,6 0 Co治疗 4 6例 )的临床资料 ,并对他们作了长期随访。结果 放射治疗后总缓解率达 90 % ,临床疗效显著 ,明显改善了患者生活质量。副反应以皮肤损害 (10例 )和消化道症状 (9例 )多见。结论 对于药物反应差、手术时发现胸腺瘤对周围组织有明显浸润或术后症状不稳定 MG患者加用胸腺放射治疗 。

Objective To observe the therapeutic effect on thymus radiotherapy in the patients with myasthenia gravis (MG).Methods The clinical data of 68 patients with MG treated by thymus radiotherapy (X ray radiotherapy in the deep for 22 cases, 60 Co treatment for 46 cases)in our hospital from 1957 to 1999 were analysed retrospectively.The patients were followed up long term.Results Total remission rate of patients with MG treated by radiotherapy was 90%.Clinical results were significant,the life quality of patients with MG improved greatly.The side effect with the skin injury for 10 cases and the alimentary canal symptom for 9 cases were found mostly.Conclusion The following patients can obtain obvious therapeutic effect with radiotherapy,they are those with poor efficiency to drugs,those with invasive thymoma during the operation,those with instable symptoms after the operation.