降压通脉方对高血压病左室肥厚患者血管活性物质的影响

Study on Effect of Jiangya Tongmai Recipe on Vascular Activating Substances in Patients of Hypertension with Left Ventricular Hypertrophy

目的 :本研究从心论治高血压病 ,以活血化瘀为主要治则 ,探讨高血压病心血管并发症治疗中 ,中药对血管活性物质的影响。方法 :将 37例高血压病患者随机分为中药组 (2 1例 )和对照组 (16例 ) ,分别给予降压通脉方和开搏通治疗 8周 ,比较两组治疗前后心脏收缩功能 (EF)、舒张功能 (Emax/Amax、E max)及血浆内皮素 (ET)、降钙素基因相关肽 (CGRP)、血管紧张素Ⅱ (AngⅡ )的水平。 结果 :降压通脉方可增强左室舒张功能、左室收缩功能 ,降低血浆中ET和AngⅡ水平 ,升高血浆中CGRP水平。 结论 :降压通脉方在改善左室功能及血管活性物质方面取得较好效果 ,从多途径、多环节防治高血压病及其心血管并发症。

To study the effect of Jiangya Tongmai Recipe (JYTMR), a Chinese herbal medicine preparation for activating blood circulation to remove stasis, on vascular activating substances in treating patients of hypertension with left ventricular hypertrophy. Methods: The 37 patients with hypertension were randomly divided into two groups, the treated group (n=21) and the control group (n=16). They were treated with JYTMR and captopril respectively for 8 weeks. Left ventricular mass weight (LVMI), peak flow velocity of early diastole (Emax), peak flow velocity of atrial contraction (Amax), Emax/Amax, ejection fraction (EF), as well as levels of plasma endothelin (ET), calcitonin gene related peptide (CGRP) and angiotensin Ⅱ (AngⅡ) were measured before and after treatment and compared. Results: JYTMR could enhance the left ventricular dilation and contractile functions, lower the levels of plasma ET and AngⅡ and increase the level of plasma CGRP. Conclusion: JYTMR shows good effect in improving left ventricular function and regulating vascular activating substances, it could prevent and treat hypertension and its complications for prolonged treatment via multiple paths and links.