氯沙坦降压疗效及对内皮素和心钠素的影响

Therapeutic effect of losartan on hypertension and its effects on the plasma ET-1 and ANP

目的 探讨氯沙坦的降压效果及对内皮素 (ET 1)及心钠素 (ANP)的影响。方法 对 78例高血压病患者分别用氯沙坦和依那普利治疗 ,记录 2 4h动态血压监测 (ABPM )和每日偶测血压的变化 ,测定治疗前后血浆ET 1、ANP水平变化。两组进行比较。结果 氯沙坦组降压作用同依那普利组比较 ,差异无显著性。氯沙坦组收缩压 (SBP)及舒张压 (DBP)的降压谷 峰 (T P)比值分别为 64 .4%和 60 .1%。两组血浆ET 1和ANP均降低。结论 氯沙坦是一种安全有效的降压药 ,服药后ET 1和ANP降低 。

Objective To investigate the efficacy of Losartan in reducing blood pressure and its effects on the plasma ET 1 and ANP.Methods Losartan and Enapril were administered respectively to seventy eight hypertensive patients.ABPM was recorded and blood pressure was measured every day.The plasma ET 1 and ANP were also measured before and after treatment.The two groups were compared.Results The efficacy of Losartan in reducing blood pressure was not significantly different from that of Enapril group.The ratio of trough:peak (T/P)of decompression of systolic blood pressure (SBP) and diastolic blood pressure (DBP) in losartan group was 64.4% and 60.1%.The plasma ET 1 and ANP decreased significantly in both groups.Conclusion Losartan is a safe and effective antihypertension agent.ET 1 and ANP decreased after treatment,which is beneficial for hypertensive patients.