二甲双胍对肥胖型糖耐量减低的干预作用

Intervenient effect of dimethyldiguanide on obesity patients with impaired glucose tolerance

目的 观察二甲双胍对肥胖型糖耐量减低 (IGT)患者糖代谢血脂及体重及其转归的影响。方法 对 10 7例IGT患者进行为期 1年的对照性二甲双胍治疗研究。结果 治疗组 1年间转变为糖尿病 (DM)者 2例 (4 .3 4% ) ,维持IGT者 5例 (10 .87% ) ,转变为正常者 3 9例 (84.78% ) ,而对照组上述病例数分别为 5 (10 .42 % )、3 2 (66.67% )和 11(2 2 .92 % )。与对照组相比 ,二甲双胍治疗能改善空腹血糖、餐后血糖和体重指数 (BMI) ,差异均有显著性意义 (P <0 .0 5 )。

Objective To observe the intervenient effect of dimethyldiguanide on the gluco metablism,blood lipids and body weigh of obesity patients with impaired glucose tolerance (IGT).Methods 107 patients with IGT were treated with dimethyldiguanide for one year.Results During the period of treatment,in treatment group,2 cases (4.34%) suffered from diabetes mellitus (DM),5 cases (10.87%) continued to the impaired glucose tolerance and 39 cases (84.87%) returned normal;however,in control group,the data were 5 cases (10.42%),32 cases (66.67%) and 11 cases (22.92%) respectively.Dimethyldiguanide could improve fasting blood glucose,postprandial blood glucose and body weight index (BMI).There was a significant difference between the two groups (P<0.05).Conclusion Dimethyldiguanide is quite suitable for treating the obesity patients with impaired glucose tolerance.