摘要
应用在体子宫痉挛 (类痛经反应 )的病理模型和经典的抗炎模型 ,对益母草主要化学成分总生物碱进行了抗炎、镇痛、抗痛经实验研究。结果表明益母草总生物碱对缩宫素引起的大鼠在体子宫和前列腺素 E2 (PGE2 )引起的小鼠在体子宫强烈收缩有显著的缓解作用 ,且表现出一定的量效关系 ;对热刺激引起的疼痛反应也具有缓解作用 ;对角叉菜胶引起的大鼠渗出性炎症和肉芽肿形成的慢性炎症 ,有明显的抑制作用。提示益母草总生物碱有明显的抗炎。
The pharmacological actions, anti-dysmenorrhea effect and anti-inflammatory effect of total alkaloids from Leonurus (L.) heterophyllus Sweet were studied on a dysmenorrhea model and on an classic inflammatory model in rats and mice. The results showed the total alkaloids from L. heterophyllus had obvious remission effect on oxytocin-induced dysmenorrhea in rats and PGE 2-induced dysmenorrhea in mice in a dose dependent manner to some extent. The results also showed the total alkaloids from L. heterophyllus had obvious inhibition on inflammation induced by carrageenin and cotton ball. The findings suggest that the total alkaloids from L. heterophyllus had obvious effects of anti-dysmenorrhea and anti-inflammation.
出处
《华中科技大学学报(医学版)》
CAS
CSCD
北大核心
2002年第2期168-170,共3页
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
关键词
抗炎
抗痛经
益母草
总生物碱
药理
实验研究
Leonurus heterophyllus
total alkaloids
anti-inflammation
anti-dysmenorrhea