喷昔洛韦软膏治疗颜面单纯疱疹35例

Clinical Effectiveness of Penciclovir Ointment for the Treatment of Facial Herpes Simplex: A Report of 35 Cases

目的 :观察 1%喷昔洛韦软膏治疗颜面单纯疱疹的临床疗效和安全性。方法 :采用随机双盲对照方法 ,共观察颜面单纯疱疹患者 68例 ,治疗组 3 5例 ,用 1%喷昔洛韦软膏治疗 ;对照组 3 3例 ,用 3 %阿昔洛韦软膏治疗。两组用法均为 :每 2h 1次 ,每天 5次 ,共 7d。结果 :治疗组止疱时间、水疱完全消失时间、症状消失时间、痊愈时间、结痂时间均短于对照组 ,差异有显著性 (P <0 .0 5 ) ,无不良反应。结论

Objective:To observe the efficacy and safety of 1% penciclovir ointment in treating the facial herpes simplex. Methods:Using a double blind and randomized controlled trial design, a total of 68 patients with facial herpes simplex were divided into two groups, 35 patients in the treatment group treated with 1% penciclovir ointment, while the other 33 in the control group with 3% acyclovir ointment. Results:It was found that the time needed for stopping occurrence, scab and complete resolution of vesicle, as well as for resolution of symptoms and complete recovery in the treatment group was significantly shorter than that in the control group ( P <0.05) . And no side effect was noted. Conclusion:Using 1% penciclovir ointment for the treatment of facial herpes simplex can be of high effectiveness and considerable safety.