非格司亭治疗化疗后中性粒细胞减少疗效观察

Filgrastim Accelerating the Recovery of Chemotherapy-induced Reduce of Neutrophilic Granulocytes in Patients with Malignant Lymphocytosis

目的 :观察非格司亭对化疗后中性粒细胞减少的疗效。方法 :恶性淋巴细胞增生性疾病患者 68例 ,分为治疗组 40例 ,分别以EACOP方案及VDP L方案化疗后 ,应用非格司亭 15 0 μg ,iv ,5d或sc ,4～ 14d。观察其血清粒细胞集落刺激因子 (G CSF)浓度及骨髓AKP积分。对照组 2 8例 ,单用化疗 ,未用非格司亭。结果 :与对照组相比 ,治疗组中性粒细胞数恢复时间治疗组缩短 (P <0 .0 5 ) ,感染机会减少 (P <0 .0 5 ) ,但化疗期病死率未见降低。部分病例发现骨髓AKP积分增高、血清G CSF浓度增高。结论 :非格司亭促进化疗后中性粒细胞恢复疗效明显 ,并减少继发感染的机会 。

Objective: To observe the effect of filgrastim in the recovery of chemotherapy induced reduce of neutrophilic granulocytes. Methods:40 patients suffered from malignant lymphocytosis were treated with the EACOP or VDP L protocol and then with intravenous injection of 150 μg of filgrastim for 5 days, or sc for 4～14 days. The concentration of the serum G CSF was measured and the AKP integral of bone marrow calculated. Results:Compared with the control group, the time needed for the recovery of decreased number of the neutrophilic granulocytes was shorter in the treatment group (P<0.05), and the incidence of infections lower P<0.05. However, the death rate during chemotherapy remained the same. Increased AKP intigral of bone marrow and the serum G CSF concentration were observed in some patients. Conclusion:Filgrastim has a significant effect in promoooting the recovery of neutrophlic granulocytes and very mild side effects.