体表高频超声对兔动脉粥样硬化消退治疗的评价

Evaluation of the treatment of atherosclerosis regression in the rabbit model by high-frequency ultrasound

目的 评价体表高频超声技术检测动脉粥样硬化消长改变的可靠性。方法 将 60只兔分为正常组、动脉粥样硬化自然消退组、舒降之组、普罗布考组、开搏通组、中药组。于实验开始、12周末、2 4周末测量腹主动脉内 -中膜厚度 (IMT)、动脉内径 (D)、血流速度 (V )和内中膜校正的声学密度值 (AIIc % )。对比超声测量的IMT与病理测值。结果 病理测量的IMT与超声测值差异无显著性意义 (P >0 .0 5 ) ;服药组IMT均显著低于自然消退组 (P <0 .0 5 ) ,服药后IMT厚度依次为舒降之组 <普罗布考组 <中药组 <开搏通组 <自然消退组。消退治疗后AIIc %均显著增高 (P <0 .0 5 ) ,依次为普罗布考组 >舒降之组 >中药组或开搏通组。结论 体表高频超声技术可准确评价动脉粥样硬化病变 ,并可作为随访动脉粥样硬化消长改变的可靠方法。

Objective To assess the value of high frequency ultrasound imaging technique in monitoring the progression or regression of atherosclerosis (AS) plaque.Methods Sixty male New Zealand rabbits were divided randomly into normal group,regression control group(RC),simvastatin group,probucol group,captopril and chinese medical capsule group.The intima media thickness (IMT),diameter (D),flow velocity (V) and AIIc value of abdominal aorta were measured with high frequency ultrasound at the beginning,the 12th and 24th week of the experiment.Results IMT of AS model group was thicker than that of normal group.The IMT measured under a light microscope showed no significant difference with values measured in ultrasound image (P> 0.05 ).The IMTs of 4 drug therapy groups were thinner than regression control group (P< 0.05 ).At the 24th week,IMT of 5 groups of rabbits were decreased in following: regression control group>captopril group>capsule group>probucol group>simvastatin group.The AIIc% in 4 drug therapy groups were significantly higher than AS model group (P< 0.05 ).Conclusions High frequency ultrasound imaging technique provides an reliable method in monitoring the atherosclerosis progression or regression