围产因素与新生儿缺氧缺血性脑病的相关性研究

A Correlation Study Among Perinatal Factors and the Neonatal Hypoxic lschemic Encephalopath.

【目的】 探讨围产期各种危险因素与新生儿缺氧缺血性脑病 (HIE)的发病关系。 【方法】 对 2 0 0 0年 8月～ 2 0 0 1年 2月的 6 8例HIE患儿进行回顾性调查研究 ,同时随机抽取 34例新生儿生理性黄疸患儿做对照 ,采用多元逐步回归分析的方法筛选发病的危险因素。 【结果】 两组患儿中 8个围产因素存在显著的统计学差异 ,作多元逐步回归分析表明 :胎儿宫内窘迫和 /或羊水Ⅱ～Ⅲ度污染、妊高症、早产、胎头吸引等为主要的危险因素。 【结论】 临床医师对造成HIE的各种围产期高危因素应提高预见性 ,及早采取预防措施 ,对HIE患儿进行早期综合干预。

To study the correlation among perinatal factors and neonatal hypoxic ischemic encephalopath. According to 2∶1 matched case control study design,a retrospective analysis was carried out for 68 neonates with hypoxic ischemic encephalopath and 68 neonates with physiological jaundice,the risk factors was scaled by stepwise regression analysis. There was a significant difference of perinatal factors in two groups.With stepwise regression analysis,the main dangerous factors were in proper order:fetal intrauterine distress and/or meconium stained amniotic fluid Ⅱ～Ⅲ,edema proteinuria hypertension syndrome,premature birth and vacuume extraction of fetal head. [Conclusions] Clinical doctors should improve the predictability of high risk factors,and take preventive measure in early stage,administrate the intervention events for neonatal hypoxic ischemic encephalopath.