摘要
目的 :对性激素在脑膜瘤发生发展中的作用进行分析。方法 :检测脑膜瘤患者术前的性激素水平。结果 :脑膜瘤患者的外周血的孕激素和雄激素水平下降 ,雌激素水平相对或绝对上升 ,卵泡刺激素 (FSH)和黄体生成素 (LH)无升高。结论 :雌孕激素的比例失调可能是脑膜瘤发生的重要诱因 ;它们可通过脑膜中广泛存在的雌激素受体 (PR)与雄激素受体 (AR)起作用 ,而其中起主导作用的可能是PR。
Objective:To analyze the function of sexual hormones in the oncogenesis of meningioma.Method:The level of sexual hormones was detected in the peripheral blood of meningioma patients with radioimmunology.Result:the level of progestrone and androgen in the peripheral blood was rev eled to decrease,however,the level of estrogen was revealed to relatively or abs olutely elevated.Conclusion:From all of the data in our experiments,it was reasonable to assume that the disubance of the ratio between progestrone and estrogen may play an important role in the progress of meningioma.These sexual hormones could interact with the corresponding receptors,especially PR,which had bee n shown to express widely in meningiomas.
出处
《华西医学》
CAS
2002年第1期14-15,共2页
West China Medical Journal
关键词
脑膜瘤
性激素
受体
s:meningioma
sexual hormone
receptor
