1Burt AD.Molecular regulation of hepatic fibrosis;an integrated cellular response to tissue injury[J].J Biol Chem,2000,275∶2247-2250.
2Li D,Friedman SL.Liver fibrogenesis and the role of hepatic stellate cells:new insight and prospects for therapy[J].J Gastroenterol Hepatol,1999,14(7)∶618-633.
4Elvira Olaso,Friedman SL.Molecular regulation of hepatic fibrosis[J].J Hepatol,1998,29∶836-847.
5Cohen P.The search for physiological substrates of MAP and SAP kinase in mammalian cells[J].Trends Cell Biol,1997,7∶353-361.
6Pawdon T.Protein modules and signaling networks.Nature[J].1995,373∶573-578.
7Marshall CJ.Specificity of receptor tyrosine kinase signaling:Transient versus sustained extracellular signal-regulated kinase activation[J].Cell,1995,80∶179-191.
8Pellegrini S,Dusanter FI.The structure,regulation and function of the Janus Kinase(JAKs)and the signal transducers and activators of transcriptions(STATS)[J].Eur J Biochem,1997,248∶615-633.
9Alexander Levitzki,Aviv Gazit.Tyrosine kinase inhibition:an approach to drug development[J].Science,1995,267∶1782-1787.
10Pinzani M,Marra F,Carloni V.Signal transduction in hepatic stellate cells[J].Liver,1998,18∶2-13.
3Kmiec Z. Cooperation of liver cells in health and disease. Adv Anat Embryol Cell Bio1 2001;161:1-151.
4Anania FA, Womack L, Jiang M, Saxena NK. Aldehydes potentiate alpha(2)(I) collagen gene activity by JNK in hepatic stellate cells. Free Radic Biol Med 2001;30:846-857.
5Svegliati-Baroni G, Ridolfi F, Di Sario A, Saccomanno S, Bendia E, Benedetti A, Greenwel P. Intracellular signaling pathways involved in acetaldehyde-induced collagen and fibronectin gene expression in human hepatic stellate cells. Hepatology,2001;33:1130-1140.
6Iredale JP, Benyon RC, Pickering J, McCullen M, Northrop M,Pawley S, Hovell C, Arthur MJ. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors.J Clin lnvest 1998;102:538-549.
7Marra F, Delogu W, Petrai I, Pastacaldi S, Bonacchi A, Efsen E, Aleffi S, Bertolani C, Pinzani M, Gentiltni P. Differential requirement of members of the MAPK family for CCL2 expression by hepatic stellate cells. Am J Physiol Gastrodntest LiverPhvsiol 2004;287:G18- G26.
8Li J, Hu W, Baldassare JJ, Bora PS, Chen S, Poulos JE, O'Neill R, Britton RS, Bacon BR. The ethanol metabolite, linolenic acid ethyl ester, stimulates mitogen-activated protein kinase and cyclin signaling in hepatic stellate cells. Life Sci 2003;73:1083-1096.
9Cariers A, Reinehr R, Fischer R, Warskulat U, Haussinger D. c-Jun-N-terminal kinase dependent membrane targeting of CD95 in rat hepatic stellate cells. Cell Physiol Biochem 2002;12:179-186.
10Anania FA, Womack L, Jiang M, Saxena NK.Aldehydes potentiate alpha(2)(I) collagen gene activity by JNK in hepatic stellate cells.Free Radic Biol Med 2001;30:846-857.
