摘要
目的:通过检测鼻变态反应病人外周血细胞因子水平变化,了解其在发病机理中的作用。方法:对89例交链孢霉变态反应性鼻炎病人血清T细胞亚群、IL-2、IL-6和B细胞生长因子(BCGF)活性水平进行了检测。结果:显示交链孢霉鼻变态反应病人血清IL-2、IL-6、BCGF活性水平升高,与对照组比较差异显著;血清T细胞亚群CD4/CD8比值大大高于对照组,存在显著差异。结论:T细胞及其分泌的细胞因子和B细胞分化对IgE的生成具有调节作用,它们可能参与了Ⅰ型变态反应病的发生。
Objective: Our purpose is to observe the function of Th1/Th2 subsets in allergic rhinitis with altemaria sp. Methods: The level of some cytokines in eighty-nine patients suffering from allergic rhinitis with altemaria sp were observed. Results:The results showed that the activities of serum IL-2,IL-6 and BCGF were increased in those patients. The differences of IL-2,IL-6 and BCGF between the group of patients and controls were statistically significant (P<0.05). Conclusion: The differences of CD4/CD8 radio between the two groups were also significant. It thus suggest that T lymphocytes, their secreting cytokines and B lymphocyte differentiation have regulatory effects on the production of IgE.
出处
《重庆医科大学学报》
CAS
CSCD
2002年第1期69-70,共2页
Journal of Chongqing Medical University