CD44v6蛋白在子宫颈鳞状上皮细胞癌中的表达及临床意义

Clinical significance of expression of CD44v6 protein in cervical squamous cell cancer

目的： 探讨ＣＤ４４ｖ６蛋白表达与宫颈鳞癌发生发展的关系。方法： 应用ＳＰ（Ｓｔｒｅｐｔａｖｉｄｉｎ-Ｐｅｒｏｘｉｄａｓｅ）免疫组化染色方法，检测１０例正常宫颈组织、４４例不典型增生、１６例原位癌和５５例宫颈鳞癌ＣＤ４４ｖ６蛋白的表达。结果：不典型增生的阳性表达率显著高于正常宫颈组（Ｐ＜０．０５）；原位癌的阳性过度表达率显著高于不典型增生（Ｐ ＜０．０５）；鳞癌阳性表达率显著高于原位癌 （Ｐ ＜０．０５）。ＣＤ４４ｖ６蛋白表达与宫颈鳞癌临床分期、淋巴结转移有关，与组织学分级无关。结论：ＣＤ４４ｖ６与宫颈鳞癌的发生发展相关，与肿瘤浸润和转移相关；检测其表达既可作为早期癌变出现的指标，也可是判断宫颈鳞癌转移的有用指标。

Objective: To evaluate the relationship between CD44 splice variant V6 (CD44v6) expression and carcinogensis and progression of cervical cancer. Methods: Immunohistochemistry was used to examine the CD44v6 protein expression in 10 cases of cervical squamous cell cancer, 44 cases of dyspasia and 55 cases of cervical squamous cell cancer. Results: The CD44v6 positive rate was higher in cervical dyspasia than in normal cervical tissues (P <0.05). The positive rates of overexpression in cervical carcinoma in situ was higher than in dyspasia. The positive rates of expression CD44v6 in cancer were higher than in cervical carcinoma in situ (P< 0.05). The expression of CD44v6 protein showed difference between metastasis in lymph node and clinical stages of differentiation. Conclusion:The results indicated that the expression of CD44v6 may be linked with cervical tumourigenesis and progression. CD44v6 expression analysis could not only aid the early diagnosis of cervical cancer and its metastasis, but also beuseful as a prognostic indicator.