摘要
目的:回顾分析高剂量率192Ir近距离治疗加体外照射治疗宫颈癌的疗效及生存率。 方法: 1993年5月至1997年5月,54例子宫颈癌采用高剂量率192Ir近距离加体外照射治疗,其中Ⅰ期2例,Ⅱ期29例,Ⅲ期21例,Ⅳ期2例。体外和腔内照射A点总量为65~85Gy,B点剂量50~70Gy,治疗时间6~8周。 结果:本组总的1、3、4年生存率81.5%、68.5%、61.1%。Ⅰ、Ⅱ、Ⅲ、Ⅳ期4年生存率分别为100%、75.9%、42.8%和0%,临床分期是决定预后的重要因素。放射性直肠炎及放射性膀胱炎发生率分别是31.5%和11.1%。结论: 宫颈癌的腔内与体外放射治疗是其有效的治疗手段,但如何进一步提高治愈率,降低并发症仍是今后研究的方向。
Objective: To analyze retrospectively results of cervix carcinoma treated by high dose rate 192Ir intracavitary brachytherapy and external irradiation. Methods: From May 1993 to May 1997,54 cases of cervix carcinoma were treated by combined external radiation with brachytherapy . The patient population consisted of 2 cases with stageⅠ disease , 29 cases with stage Ⅱ disease , 21 cases with Stage Ⅲ disease and 2 cases with stage Ⅳ disease . The total dose of the external and intracavitary irradiation at point A and B was 65~85Gy and 50~70Gy ,respectively. The total treatment time was 6~8 weeks . Results: The survival rate of 1、3、4 year after radiotherapy was 81.5%,68.5% and 61.1% ,respectively. The 4-year survival for stages Ⅰ、Ⅱ、Ⅲ and Ⅳdisease were 100%、75.8%、42.8% and 0% , respectively .The clinical stage of disease is an important prognostic factor . The incidence of complication was 31.5% for radiation proctitis and 11.1% for cystitis. Conclusion:HDR brachytherapy with external irradiation for the cervix carcinoma is an effective method. To improve tumor control and reduce complication rate more research is necessary.
出处
《重庆医科大学学报》
CAS
CSCD
2002年第1期86-88,共3页
Journal of Chongqing Medical University