208例SLE临床和免疫学特征分析

Analysis of clinical and immunologic manifestations in 208 patients with systemic lupus erythematosus

为探讨皮肤科门诊定期就诊的SLE患者临床特征,自身抗体分布及长期皮质类固醇治疗引起的副作用,统计分析了208例SLE的首发症状及病程中临床表现和自身抗体分布情况,并分年龄、性别组进行分析,比较。结果:所有患者一般特征,临床表现和免疫学特征和国内外报道基本一致,首发症状为蝶形红斑者占60.58%,少年组及年轻男性组内脏受累重,皮质类固醇副作用以浅表真菌感染最常见。

To explore the clinical features, autoantibodies and side effect result from long term steroid treatment of the outpatients with SLE. Data concerning the characteristics at the onset and the chinical features, autoantibodies was analysed and compared with statistical method, especially for childhood-onset patients and young male patients. General characteristics of clinical and immunological features of all patients basically accord with reports from China and abroad, the occurrence of butterfly shaped erythema as the first symptom was 60.58%. Juvenile and young male patients have more severe involvement of internal organs,the most frequent side effect result from steriod is superficial mycoses.