缬沙坦治疗老年糖尿病肾病的临床评价

Clinical evaluation of valsartan in treatment of diabetic nephropathy in elderly patients

目的 观察血管紧张素Ⅱ1型受体拮抗剂缬沙坦对于伴有蛋白尿的老年糖尿病肾病患者的疗效及肾脏保护作用。方法 测定38例伴有蛋白尿的老年糖尿病肾病合并高血压患者缬沙坦治疗前后的24h尿蛋白定量、尿α -微球蛋白、尿免疫球蛋白G及尿转铁蛋白。 结果 缬沙坦可以显著降低老年糖尿病肾病患者尿中的蛋白含量 (P<0.001) ,同时不影响患者的血脂、血钾、血糖、血尿酸水平。结论 缬沙坦对于肾脏具有明显的保护作用 。

Objective To observe the effect of angiotensinⅡ1 receptor antagonist(AT1Ra) valsartan in treatment of diabetic nephropathy in elderly patients.Methods Thirty eight elderly diabetic nephropathy patients with hypertension and proteinuria were treated with valsartan.The 24-hour urinary protein(UAER),urinary α-microglobin(U - α 1MG),urinary immunoglobulin G(U-IgG),urinary transferrin(U-TRF) were measused before and after treatment.Results Valsartan reduced proteinuria significantly(P<0.01) in elderly diabetic nephropathy patients with hypertension.Conclusion Valsartan significantly protect renal function in elderly diabetic nephropathy patients,and is better toleranted by patients.