内源性尿嘧啶类物质比值在5-氟尿嘧啶化疗中毒性预测价值的临床研究

The Predictable Role of Endogenous Uracil Derivatives Ratio in 5-Fu Chemotherapy Toxicity

目的：评价内源性二氢尿嘧啶（ＵＨ２）与尿嘧啶（Ｕ）的比值（ＲＵＨ２／Ｕ）５－氟尿嘧啶（５－Ｆｕ）化疗方案中与５－氟尿嘧啶血药浓度（Ｃ５Ｆｉ）、消化系统毒性级别的相关关系，为５－氟尿嘧啶化疗方案的调整及剂量个体化提供依据。方法：对２０例以５－氟尿嘧啶化疗的鼻咽癌病人，化疗前测定ＲＵＨ２／Ｕ，化疗中测定５－氟尿嘧啶血药浓度，化疗后评价５－氟尿嘧啶毒性并进行相关分析。结果：ＲＵＨ２／Ｕ与Ｃ５Ｆｕ、５－氟尿嘧啶致腹泻、口腔粘膜毒性均具显著相关性。结论：ＲＵＨ２／Ｕ值大小可作为评价５－氟尿嘧啶临床用药的依据应用于疗效及毒性的预测。

OBJECTIVE: To investigate the relationship between the UH_2-U ratio,5- Fu concentration and toxicity in 20 nasopharynx patients and to discover if the UH_2-U ratio could be used as an indication to adjust the dose of 5Fu or to change the therapy regimen. METHODS: The plasma samples from 20 nasopharynx patients were collected, Endogenous uracil and dihydrouracil were assayed by HPLC as previous reported. The concentration of 5-Fu was determined during the chemotherapy and its toxicity was evaluated after the therapy. The correlation between them were studied. RESULTS:The result showed that the endogenous UH_2-U ratio were correlated to the concentration of 5-Fu and the toxicity induced by the 5-Fu. CONCLUSIONS: The result indicated the UH_2-U ratio can be used to predicate the toxicity of 5-Fu and to adjust the dose of 5-Fu before the treatment.