低氧下HPA轴应激系统的变化

The HPA of ratresponse to acute hypoxia stress

大鼠在 5 km和 7km海拔高度的低氧环境暴露下 2 4 h,其全血中促肾上腺皮质素释放因子 (CRF)水平 ,血浆去甲肾上腺素 (NE)和皮质酮水平随海拔升高而升高 ,使用 6 - Hydroxydopam ine hydrochloride(6 - OHDA)试剂损毁中枢儿茶酚胺能神经元后 ,低氧对血浆皮质酮的刺激作用被部分抑制 .高原鼠兔经受如上的低氧暴露 ,未表现出同大鼠类似的神经内分泌变化 .因此 ,本研究提示低氧应激作用于大鼠 ,其下丘脑 -垂体 -肾上腺皮质 (HPA)系统和交感神经 -儿茶酚胺系统被激活 .高原鼠兔因已完全适应低氧环境 。

The presentstudy was designed to examine the effects of hypoxia on the neuroendocrine system of rats and Plateau native mammals ( Ochotona curzoniae) . Corticotropin releasing factor ( CRF) contents in whole blood,norepinephrine ( NE) and corticosterone levels in plasma increased with increase of altitude after rats were exposed to 5 km and 7km altitude for 2 4 h. The increased corticosterone level was partly inhibited when the central sympathetic nervous system was pretreated with 6- OHDA intracere- broventricularly.Elevated plasma CRF and corticosterone levels in rats were not observed in Ochotona curzoniae after hypoxia stress.These results suggestthatacute hypoxia activates the Hypothalamic- Pitu- itary- Adrenal( HPA) axis and perhaps also the sympathetic nervous system in rats,but not in Ochotona curzoniae as the animal adapted well genetically to hypoxic environment .