慢性肾衰血透患者的细胞免疫学研究

IMPAIRED CE LLU LAR IMMUNE RESPONSE IN CHRONIC RENAL FAILURE

测定50例慢性肾衰血透患者外周血T淋巴细胞亚群,同时测定其中20例病人外周血淋巴细胞白细胞介素2(IL-2)产生能力及 IL-2受体活性。发现患者淋巴细胞亚群绝对数显著减少。透析时期<1年与>1年两组间无显著差异。患者的IL-2活性与IL-2受体活性与正常对照差异无显著性,说明慢性肾衰血透患者免疫功能低下与其淋巴细胞正群绝对数下降有关。

Fifty patients receiving hemodialysis for their chronic renal failure were studied. The results show that the average relative proportion of total T cells and T_4 and T_8 subsets has no difference in the controls and uremic groups. The relative proportion of T lymphocytes was also not different in patients undergoing dialysis for less than one year or for a longer time. Absolute numbers of T lymphocyte subpopulations had striving differences in controls and uremic patients. The absolute number was significantly reduced in the dialysis patients,The activities of IL-2 and IL-2 proliferation were not different in controls and uremic groups.