常规用纳洛酮治疗中、重度新生儿缺氧缺血性脑病的疗效观察

Clinical observation of treating the moderate and severe neonatal hypoxic ischemic encephalopathy with naloxone

目的 探讨纳洛酮对中重度新生儿缺氧缺血性脑病的治疗效果。方法 将 96例中重度缺氧缺血性脑病患儿随机分为治疗组和对照组 ,对照组按常规综合治疗 ,治疗组在综合治疗的基础上加用纳洛酮 ,观察两组间治疗效果的差异。结果 治疗组呼吸衰竭症状 89.5 % (34/ 38)在 72小时以内消失 ,对照组为 6 6 .7% (2 0 / 30 ) ,差异有显著性 (χ2 =4 .0 3,P <0 .0 5 ) ;两组在意识障碍、原始反射、肌张力恢复时间和住院时间上作对照 ,差异性非常显著 (P <0 .0 1) ;治疗组总有效率 92 % ,对照组 73.9% (χ2 =6 .4 1,P <0 .0 5 )。结论 纳洛酮可促进中重度新生儿缺氧缺血性脑病患儿的苏醒 ,缩短病程。

Objectives To explore the therapeutic effect of naloxone on the moderate and severe neonatal hypoxic ischemic encephalopathy(HIE).Methods Neonates with HIE were divided into two groups of routine(n=46) and naloxone treatments(n=50) at random.The recovery time of various features of HIE were investigate.Results In the naloxone treatment group,89.5%(34/38) of the symptoms of respiratory failure disappeared within 72 hours,while in the routine treatment group were 66.7%(20/30),there were significant differences between the groups of routine and naloxone treatments.(χ 2=4.03,P<0.05).Compared with the routine treatment group,the recovery time of the disturbance of consciousness,abnormal primitive reflexes,muscular tone and the hospitalization course were significantly shortened in naloxone treatment group(P<0.01).The general efficiency is 92% in the naloxone treatment group,while 73.9% in the routine treatment group(χ 2=6.41,P<0.05).Conclusions Naloxone is useful in promoting the revival of neonates with HIE and shortening the period of treatment of neonatal hypoxic ischemic encephalopathy.