疣状胃炎幽门螺杆菌感染与病理改变

Related study on Helicobacter pylori infection and pathological changes in verrucosa gastritis

目的 比较疣状胃炎与慢性浅表性胃炎患者的幽门螺杆菌 (Hp)感染、病理组织学改变情况 ,探讨疣状胃炎病因和病理。方法 选择胃镜下诊断为疣状胃炎的患者 5 6例 ,以快速尿素酶试验及组织学染色 (吉姆萨染色 )检测Hp感染 ,并作病理学诊断 ;另选慢性浅表性胃炎 5 8例作对照研究。结果 疣状胃炎Hp感染率为6 6 .0 7%,慢性浅表性胃炎Hp感染率为 31.0 3%,前者明显高于后者 (P <0 .0 5 ) ;疣状胃炎病理改变呈重度炎症改变者占 6 4.2 9%,慢性浅表性胃炎占 36 .2 1%,前者明显高于后者 (P <0 .0 1)。结论 ①疣状胃炎与Hp感染密切相关 ;②疣状胃炎伴有明显的病理异常 ,临床上应重视其诊治和随访。

Objective To compare the Helicobacter pylori (Hp) infection and pathological changes between verrucosa gastritis and chronic superficial gastritis patients to explore the pathogenesis of verrucosa gastritis. Methods 56 cases of verrucosa gastritis diagnosed by endoscopy were studied. The Hp infections was examined by rapid urease test and the pathological diagnosis was made on the finding of biopsy. 58 patients with chronic superficial gastritis were taken as the control group. Results The infective rate of Hp was 66.07% in verrucosa gastritis and 31.03% in chronic superficial gastritis (P<0.05). The frequency of severe inflammation in pathological changes was 64.29% in verrucosa gastritis and 36.21% in chronic superficial gastritis (P<0.01). Conclusion Verrucosa gastritis has close correlation with Hp infection and obvious pathological abnormalities. Its diagnosis, treatment and regular follow-up should be seriously concerned.