非肥胖2型糖尿病中LADA的发病状况

Condition of latent auto-immune diabetes in adults(LADA) in non-obese patients with type 2 diabetes mellitus

目的 :了解非肥胖 2型糖尿病中LADA的发病状况。方法 :依据胰岛素需要与否 ,将 14 9例非肥胖糖尿病患者分为A、B二组 ;再依据胰岛细胞抗体 (ICA)阳性与否 ,又分A组为A1组与A2组进行对比研究 ,测定胰岛 β细胞功能。结果 :A组胰岛功能明显差于B组 ,ICA阳性率则高于B组 ;A1、A2组差异尤著。结论 :在非肥胖 2型糖尿病中 ,如口服降糖药效差、ICA阳性、胰岛功能很差 。

Objective:To investigate the condition of LADA in non-obese patients with type 2 diabetes mellitus,expectially in those accompanied with secondary failure of oral hypoglycemic agents(OHA).Methods:149 non-obese patients with type 2 diabetes were divided into two groups.Group A( n =62) involved in insulin needed patients with secondary failure of OHA,and group B( n =87) comprised with insulin free patients.The comparative study on group A1 and group A2 which separated from group A was performed based on the positive or negative result of islet cell antibody(ICA). Levels of the islet B cell function were examined in all patients.Results:Compared to group B,the positive rates of ketosis,autoimmune diseases and ICA in group A were markedly higher,while the sick age,the level of full plasma C-peptide and the under curve areas of C-peptide were obviousy lower.When compared group A1 with group A2,their differences above parameters were more significantly magnified.Conclusion:LADA should be considered in those diabetic patients with non-obesity or lower body mass index,positive ICA and failure of islet B cell function,once it diagnosed,insulin should be used as early as possible.