创伤失血性休克兔肾动脉血流改变的多普勒监测

Detrmination of Renal Arterial Blow by Doppler Following Traumatic Hemorrhagic Shock in Rabbits

目的 检测创伤失血性休克 3 0、60及 12 0min时 ,兔肾动脉血流多普勒频谱的改变特征。方法 实验动物分为复苏组与对照组 ,应用Acuson12 8XP 10型彩超仪 ,测定兔肾动脉在休克后不同时间段的血流参数。结果 失血性休克后肾动脉收缩期血流峰值速度 (Vmax)、舒张期血流速度 (Vmin)和平均血流速度 (Vmean)显著减低 ,随时间呈递减趋势 ,与复苏组比较差异显著 (P <0 .0 1) ,但休克后复苏组上述诸值与休克前相比变化不明显。结论 失血性休克后肾血供随时间递减 ,采用静脉输注高渗氯化钠 右旋糖酐 (HSD)

Objective The subject of this study was to determine the Doppler spectral characteristics of rabbit renal arterial blood flow after traumatic hemorrhagic shock.Method Twelve rabbits were subjected to hemorrhagic shock (bleeding to mean arterial blood pressure of 5.33kPa and maintaining for 40 min) and divided into control(Without resuscitated) and resuscitated group (4ml/kg of hepertonic 7.5% saline and 6% dextran was administrated at the end of hemorrhagic shock). The peak sistohic velocity (Vmax), end diastolic velocity(Vmin), mean flow velocity(Vmean), of renal artery were determined with Acuson 128xp-10 color Doppler meter at 30, 60 and 120 min after hemorrhagic shock. Result The Vmax, Vmin, and Vmean were significantly decreased and progressive deteriorated in control group compared with that of resuscitated group( P <0.01), while there were no significantly difference between pre-and after shock in resucitated group.Conclusion The renal blood flow decrease progressively after hemorrhagic shock. Administraion of hypertonic 7.5% saline and 6% dextran can significantly improve the renal perfusion.