摘要
观察苏木对同种异位心脏移植大鼠心肌内颗粒酶BmRNA表达的影响。采用以Wistar大鼠为供体 ,以SD大鼠为受体 ,建立大鼠腹腔异位心脏移植模型 ,以RT PCR法检测心肌中颗粒酶 (Gra )BmRNA表达。结果表明苏木能明显降低心肌颗粒酶BmRNA的表达。苏木水煎剂有明显的抗免疫排斥作用 。
The effect of Sappan wood on the expression of granzyme B mRNA in myocardium of rats with allogenic heart transplantation were observed by means of RT PCR in the animal model of the animal model of abdominal allogenic heart transplantation.It was found that the expression of granzyme B mRNA was significantly reduced by the treatment with Sappan wood,indicating an obvious function in anti immune rejection of this drug.It suggests Sappan wood might express its immuno suppressive effect through the inhibition of granzyme B mRNA expression in myocardium.
出处
《上海免疫学杂志》
CAS
CSCD
北大核心
2002年第2期110-112,共3页
Shanghai Journal of Immunology
