胰酶胶囊与多酶片治疗胰腺炎伴消化不良症状的疗效比较

Comparison of effect of pancreatin capsules and multienzyme in treating pancreatitis with dyspepsia

目的 :比较胰酶胶囊与多酶片治疗胰腺炎伴消化不良病人的疗效。方法 :将 63例病人随机分成 2组 ,胰酶胶囊组 33例给予胰酶胶囊 2粒 ,po ,tid× 4wk ;多酶片组 30例给予多酶片 5片 ,po ,tid× 4wk ;服药后 2 ,4wk进行临床症状的积分评价。结果 :胰酶胶囊组治疗 2wk后在腹痛、饱胀、胃肠胀气、腹泻等积分分别下降了 (0 .86± 0 .13)分 ,(1.33± 0 .14 )分 ,(1.4 0± 0 .2 1)分 ,(0 .90± 0 .16)分 ;多酶片组分别下降了 (0 .13± 0 .0 3)分 ,(0 .37±0 .0 4 )分 ,(0 .36± 0 .0 7)分 ,(0 .15± 0 .0 4 )分。均P<0 .0 1。治疗后 4wk胰酶胶囊组总有效率为94 %、多酶片组为 5 7% ,2组间比较P <0 .0 5。结论

AIM: To compare the clinical effects of pancreatin capsules and multienzyme in the treatment of pancreatitis with dyspepsia in sixty three patients. METHODS: Sixty three patients were divided randomly into two groups. Thirty three patients of pancreatin capsules group were treated with pancreatin capsules, (two capsules) po , tid for 4 wk. Thirty patients of multienzyme group were treated with multienzyme (five tablets) po , tid for 4 wk. After 2,4 wk treatment, we evaluated integrals of clinical symptoms. RESULTS: Integrals of pancreatin capsules group for 2 wk treatment in abdominal pain, vomit, abdominal expend and diarrhoea reduced separately (0.86± 0.13), (1.33± 0.14), ( 1.40± 0.21), (0.90± 0.16). Integrals of multienzyme group reduced (0.13±0.03),(0.37±0.04),(0.36±0.07),(0.15±0.04). Both drugs could reduce integrals of clinical symptoms ( P < 0.01 ). After 4 wk treatment the clinical effects of pancreatin capsules group and multienzyme group were separately 94 % and 57 %. The effect of capsules group was ahead of that of multienzyme group ( P <0.05). CONCLUSION: Pancreatin capsules has much effects in the treatment of pancreatitis with dyspepsia than that of multienzyme.