国人ACE基因插入/缺失多态性与冠心病关联性Meta分析

Meta-analysis on the Association of Insertion/deletion Polymorphism of the Angiotensin Converting Enzyme Gene and Coronary Heart Disease in Chinese Population

目的:对国人血管紧张素1转换酶(ACE)基因内含子16插入(I)/缺失(D)多态性与冠心病的关联性进行Meta分析。方法:以冠心病组和健康对照组基因型分布的OR值为统计量,全面检索到相关文献并剔除不符合要求的文献,排除发表偏倚的影响。应用REVMAN3.1软件对各研究结果进行一致性检验和采用相应的数学模型进行数据合并。结果:冠心病组631例,健康对照组505例,数据合并结果DD/(ID+II)OR(95％可信区间)为2.72(2.08,3.55),P<0.01。结论:国人ACE/ID多态性的DD基因型与冠心病危险性增加有关联。

Objective: To study the association of insertion (Ⅰ)/deletion (D) polymorphism of the angiotensin converting enzymegene intron 16 (ACE/ID) and coronary heart disease (CHD) in Chinese population by the means of meta-analysis. Methods: Odds ratios of ACE/ID genotype distributions in CHD patients against healthy control were analyzed. All the related studies on ACE/ID polymorphism and CHD were identified, poor-qualified studies were excluded, and the risk of publication bias was estimated. REVMAN3. 1 software was applied for investigating heterogeneity among individual studies and summarizing effects across studies by proper statistical methods. Results: A total of 631 cases and 505 controls were included. The odds ratios (with 95% CI) of DD vs ID+Ⅱ was 2.72 (2.08,3.55) (P<0.01). Conclusion: DD genotype ofACE/ID polymorphism is associated with an increased risk of CHD in Chinese population.