2型糖尿病患者尿TGF-β_1检测的临床意义

Clinical Significance of Measurement of Urinary TGF-β1 in Patients with Type 2 Diabetes Mellitus

目的:通过测定尿转化生长因子β1(TGF-β1)探讨其与2型糖尿病患者肾脏病变的关系。方法:同期测定74例2型糖尿病患者和30例正常对照者尿TGF-β1以及24h尿白蛋白(UAE)、α1-微球蛋白(α1-MG)。结果:2型糖尿病患者24h尿TGF-β1、α1-MG均高于正常对照组,且其排泄增高的发生率随24h尿UAE的增加而增加;尿TGF-β1与α1-MG呈正相关。结论:2型糖尿病患者尿TGF-β1升高与肾脏病变的发生发展有关。

Objective: To investigate the relationship between transforming growth factor-β1 (TGF-β1) and renal damage in patients with type 2 diabetes mellitus by measuring urinary TGF-β1 . Methods: Urinary TGF-β1 , 24 hour urinary albumin excretion (UAE), and α1-microglobulin (α1-MG) were measured in 74 patients with diabetes mellitus and 30 normal controlsubjects. Results: The urinary levels of TGF-β1 and α1 -MG significantly elevated in type 2 diabetes mellitus compared withthose in normal control subjects, and the excretion increased with the increase of 24 h UAE. There was a significant correlation between TGF-β1, and α1 -MG. Conclusion: The measurement of the urinary level of TGF-β1 is useful for detection ofdiabetic nephropathy.s