急性胆源性胰腺炎致肝功能损害临床特点分析

Clinical Analysis of Liver Function Impairment Caused by Acute Biliogenic Pancreatitis

目的:分析及比较胆源性急性胰腺炎(AP)与非胆源性AP致肝功能损害临床特点。方法:35例胆源性AP,对照组为43例非胆源性AP,比较两组肝功能指标增高值、符合重症AP人数、转手术率及病死率。经治疗后第4周,比较两组异常增高的肝功能指标治愈率。结果:(1)胆源性AP组符合重症AP人数、转手术率及死亡率均较对照组高。(2)胆源性AP组中ALT、AST、ALP、GGT、TBA、SB值均较非胆源性AP组增高。(3)治疗后第4周胆源性组中增高的GGT、ALP治愈率较对照组低。结论:胆源性AP合并肝功能损害患者病情较重,肝脏储备及修复能力差,应加强对原发病的控制,以防止肝功能进一步恶化从而降低病死率。

Objective: To analyze and compare the liver function impairment caused by biliogenic AP with that caused by non-bil-iogenic one. Methods: The increased index of liver function, number of severe AP, operation rate, and the mortality were compared in 35 patients with biliogenic AP and 43 patients with non-biliogenic AP. The curative rates of abnormal liver function were compared 4 weeks after therapy. Results: (1) Number of severe AP, operation rate, and mortality in biolio-genie AP group were higher than that in control group. (2) ALT, AST, ALP, GGT, TBA, SB increased significantly in biliogenic AP group than that in control group. (3) The curative rate of increased GGT, ALP 4 weeks after therapy in biliogenic AP group was lower than that in control group. Conclusion: Patients with biliogenic AP combined with liver function impairment are more severe, and the liver function of reserve and repair is poor. We should emphasize the control of primary disease in order to prevent liver function deterioration and decrease the mortality.