乌头碱致蟾蜍心律失常和抑制心脏收缩作用的毒性分析

Virulence analysis of aconitine in action of inducing toad arrhythmia and inhibiting heart contraction

目的 :分析乌头碱 (Ac)致心律失常和抑制心脏收缩的毒性作用。方法 :用 0 .0 1～ 10 0× 10 -5mol·L-1 Ac灌流蟾蜍心脏 ,观察 Ac抑制蟾蜍心脏收缩和致心律失常的量 -效反应。结果 :Ac抑制心脏收缩作用早于致心律失常。随浓度加大 ,心脏收缩的抑制率增强 (F测验 ,P<0 .0 1) ,室早和室颤潜伏期以及心抑潜伏期缩短 ,平均抑制速率加快 ,半平衡时间缩短。结论 :Ac抑制心脏收缩和致心律失常具有明显的量反应和时反应量

OBJECTIVE:To analyze Aconitine (Ac)'s effects to induce arrhythmia and inhibit heart contraction. METHODS:By infusion of toad hearts in vitro with 0.01-100×10 -5 mol·L -1 Ac, dose response relationship is observed. RESULTS:The study indicated that inhibitory action of Ac in toad heart contraction was ahead of inducing arrhythmia, the high Ac concentration was, the larger the depressive action (F' text P <0.01), the shorter the latency time of arrhythmia (VPB and VF) and depressive action of heart,the quicker the average inhibiting rate, and the shorter the half equilibrium time were.CONCLUSION:All of these showed significantly existence of the GDRR and the TDRR.