狭叶南五味子中的抗生育活性三萜酸(英文)

Antifertility Triterpenoid Acids from Kadsura angustifolia

目的 :从狭叶南五味子茎中分离鉴定生物活性成分。方法 :采用溶剂提取及柱色谱法进行分离 ,光谱技术鉴定化合物的结构。结果 :分得 8个已知化合物及两个三萜酸的混合物 ,结构鉴定为表安五酸 (epi-anwuweizic acid,1) ,莽草酸 (shikimicacid,2 ) ,儿茶精 ((+ ) -catechin,3 ) ,poriferast-5 -en-3β,7α-diol(4 ) ,β-谷甾醇 (5 ) ,胡萝卜甙 (6) ,cerotic acid 1-monoglyceride(7) ,behenic acid 1-monoglyceride(8)及 coccinic acid(9)和安五酸 (anwuweizonic acid,10 )的混合物。结论 :9和 10的混合物体外对人蜕膜细胞和鼠黄体细胞有显著抑制作用。化合物 2～ 4,7和 8首次自五味子科植物中分得 ,化合物 1,5 ,6,9和

OBJECTIVE:To isolate and characterize bioactive compounds from the stems of Kadsura angustifolia .METHOD:The compounds were extracted with solvent,isolated by column chromatography and identified by the spectroscopic methods.RESULTS:eight compounds and a mixture of two triterpenoid acids were isolated and identified as epi anwuweizic acid (1),shikimic acid (2),(+) catechin (3),poriferast 5 en 3β,7α diol (4),β sitosterol (5),daucosterol (6),cerotic acid 1 monoglyceride (7) and behenic acid 1 monoglyceride (8),and mixiture of coccinic acid (9) and anwuweizonic acid (10).CONCLUSION:Mixture of 9 and 10 showed significant inhibitory activity against human decidual cells and rat luteal cells in vitro . Compounds 2~4,7 and 8 were first reported in the family Schisandraceae,and compounds 1,5,6,9 and 10 were isolated from K.angustifolia for the first time.