嗜酸乳杆菌治疗幽门螺杆菌感染的疗效

Clinical effect of Lactobacillus acidophilus for Helicobacter pylori

目的 :观察嗜酸乳杆菌对胃内幽门螺杆菌(Hp)的疗效。方法 :Hp感染阳性的胃、十二指肠溃疡病人 68例分嗜酸乳杆菌治疗组 (2 4例 ,用乳酸乳杆菌 1包 ,po ,bid ,硫糖铝片 1.0 g ,po ,tid)与对照组 (4 4例用雷尼替丁 0 .15 g ,po ,bid ,甲硝唑 0 .4g ,阿莫西林 0 .5 g ,硫糖铝片 1.0g均 po ,tid) ,2组均用 4wk。结果 :腹痛症状缓解率治疗组为 10 0 %(12 / 12 ) ,对照组为 95 % (18/ 19) ;溃疡愈合率分别10 0 % (15 / 15 )和 97% (4 0 / 4 1) ;Hp转阴率分别是67% (16/ 2 4 )和 75 % (33/ 4 4 ) ;血清学CagA- 基因表达IgG的ELISA检测 :治疗前 2组有 60 %的抗CagA+ IgG表达阳性 ,治疗后 ,检测阳性结果为30 % ,2组比较均P >0 .0 5。结论

AIM: To observe the therapeutical effect of Lactobacillus acidophilus for human stromach Helicobacter pylori. METHODS: The gastric ulcer and duodenal ulcer patients of Hp positive sixty eight patients were divided into two groups, Lactobacillus acidophilus treatment group (twenty four patients, Lactobacillus acidophilus one packet, po, bid, ulcermin sheet 1.0 g, po , tid) and control group (forty four patients, and ranitidine 0.15 g, po, bid, metronidazole 0.4 g, amoxicillin 0.5 g, ulcermin sheet 1.0 g, po, tid) administrated for 4 wk. Then the clinical symptom recovery, gastric mucosa Hp infection condition and Cag Hp IgG changes were observed. RESULTS: Symptom remission rate: the treatment group was 100%(12/12) and the control group was 95%(18/19). Ulcer healing rate of two groups were 100%(15/15) and 97%(40/41) in difference; there was not significantly different in the two groups ( P >0.05); (3) Hp infection rate: two groups were 67%(16/24) and 75%(33/44) in difference; Enzyme linked immunodson dent assay (ELISA) detect of serolog CagA +IgG Gene expression: Anti exprossion positive of two groups in pre treatment were 62% and post treatment positive findings 30%, there was not significantly different in two groups ( P >0.05). CONCLUSION: The study suggest Lactobacillus acidophilus has significant effect on anti Hp infection and mediate body immunity.