1Kellogg S T, Chatterjee D K, Charkrabartv A M. Plasmidassisted molecular breeding: new technique for enhancedbiodegradation of persistent toxic chemicals [J]. Science,1981 ;214:1133
2Liao J C, Delgado J. Advances in metabolic control analysis[J]. Biotechnol Prog, 1993 ;9:221
3Cameron D C, Tong L T. Cellular and metabolic engineering[J]. Appl Biochem Biotechnol, 1993 ;38: 105
4Lee S Y, Papoutsakis E T. Metabolic Engineering [M]. NewYork: Marcel Dekker, 1999: Ⅶ
5Bailey J E. Towards a science of metabolic engineering [J].Science, 1991 ;252:1668
6Stephanopoulos G, Vallino J J. Network rigidity and metabolicengineering in metabolite overproduction [J]. Science, 1991;252:1675
7Stephanopoulos G, Aristidou A, Nielsen J. MetabolicEngineering [M]. San Diego: Academic Press, 1998: 1
8Khetan A, Hu W S. Metabolic Engineering of AntibioticBiosynthetic Pathways [A]. Demain A L, Davies J E, AtlasR M, et al. Manual of Industrial Microbiology andBiotechnology 2nd [M]. Washington D C: ASM Press, 1999:717
9Nielsen J. The role of metabolic engineering in the productionof secondarv netabolites [J]. Curr Opin in Microbiol, 1998; 1(3) :330
10Khetan A, Malmberg L H, Sherman D H, et al. Metabolicengineering of cephalosporin biosynthesis in Streptomycesclav uligerus [J]. Ann N Y Acad Sci, 1996;782:17