阿尔茨海默病与家族史病例对照研究

A case-control study on family history of Alzheimer's disease

目的 探讨家族史和阿尔茨海默病 (AD)的关系。方法 采用以人群为基础的病例对照研究设计 ,病例组为 12 7例临床诊断为AD的病例 ,并以 1∶2配对 ,以年龄、性别、受教育程度为匹配条件的 2 5 4名非痴呆者作为对照 ,通过单因素分析和条件logistic回归分析 ,估计AD与家族史之间的联系强度。结果 一级亲属有痴呆病史或重性精神病史者 ,患AD危险性显著高于对照人群 (OR值分别为 6 .2 5和 8.33,P <0 .0 1)。调整混杂因子的影响后 ,一级亲属的痴呆家族史和AD的发生仍有显著联系 (调整后OR =2 .0 7,P =0 .0 18)。结论 AD可能存在家族史聚集性。

Objective To explore the relationship between Alzheimer's disease and its family history of the patients. Methods Stratified analyses and logistic regression analysis were used to examine the association between Alzheimer's disease and its family history exposure in 127 cases and 254 matched controls from a population-based case-control study. Results The risk of Alzheimer's disease was significantly higher in those who had at least one first-degree relative with dementia or major psychosis as compared to those who had no dementia or major relatives with psychosis (OR= 6.25; 8.33). Adjusted for age and level of education, family history of dementia was still associated with Alzheimer's disease positively (OR= 2.07). Conclution This study provides evidence that familial aggragation of Alzheimer's disease might txst among people living Beijing.