3Ganem D, Varmus HE. The molecular biology of the hepatitis B viruses. Annu Rev Biochem, 1987, 56: 651-693.
4Shirakata Y, Kawada M, Fujiki Y, et al. The X gene of hepatitis B virus induced growth stimulation and tumorigenic transformation of mouse NIH3T3 cells. Jpn J Cancer Res, 1989, 80: 617-621.
5Luber B, Arnold N, Sturzl M, et al. Hepatoma-derived integrated HBV DNA causes multi-stage transformation in vitro. Oncogene, 1996, 12: 1597-1608.
6Lee TH, Finegold MJ, Shen RF, et al. Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice. J Virol, 1990, 64: 5939-5947.
7Zhu H, Wang Y, Chen J, et al. Transgenic mice expressing hepatitis B virus X protein are more susceptible to carcinogen induced hepatocarcinogenesis. Exp Mol Pathol, 2004, 76: 44-50.
8Balsano C, Billet O, Bennoun M, et al. Hepatitis B virus X gene product acts as a transactivator in vivo. J Hepat, 1994, 21: 103-109.
