2Selkoe DJ.Biology of β-amyloid precursor protein and the mechanism of Alzheimer disease[].Alzheimer disease.1999
3Lahad E,Bird TD,et al.Genetic factors in Alzheimer′s disease: a review of recent advances[].Annals of Neurology.1996
4Clark RF,Huton M,Fuldner R,et al.The structure of the chromosome 14 mutations[].Neuron.1995
5Geroge S.Role of genetics in tests of genotype, status, and disease progression in early onset Alzheimer′s disease[].Neurobiology of Aging.1998
6Ehnholm C,Luka M,Kusi T,et al.Apolipoprotein E polymorphism in the Finnish Population : gene frequencies and relation to lipoprotein in concentration[].Journal of Lipid Research.1986
7Blennow K,Hesse C,Fredmam P,et al.Cerebrospinal fluid apolipoprotein E is reduced in Alzheimer disease[].New Areport.1994
8Strittmatter WJ,Saunders AM,Schmechel D,et al.Apoliprotein E :high avidity binding toβ-amyloid and increased frequency of type 4 allel in late-onset familial Alzheimer′s disease[].Proceedings of the National Academy of Sciences of the United States of America.1993
9Corder EH,Sanghra,D. K,Ferrell,R. E,et al.Gene dose of the apolipoprotein E type-4 allele and the risk of Alzheimer′s disease in lateonset families[].Science.1993
10Rogaeva E,Premkumar S,Song Y,et al.Evidence for an Alzheimer disease susceptibility locus on chr 12, and for further locus heterogeneity[].The Journal of The American Medical Association.1998
同被引文献16
1[1]Collins FS, McKusick VA. Implications of the human genome project for medical science[J]. JAMA,2001,285:540-544.
2[5]Brzustowicz LM,Hodgkznson KA,Chow EW,et al.Cocation of a major susceptibilitylocus for familial schizophrenia on chromosome 1q 21～q22[J].Science,2000,288:678-682.
3[8]Farrer LA, Cupples LA, Haines JL, et al. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Aizheimer disease[J]. JAMA, 1997,278:1349-1356.
4[9]Siest G, pillot T, Regis-Bailly A, et al. Apolipoprotein E: an important gene and protein to follow in laboratory medicine[J]. Clin Chem, 1995,41:1068-1086.
5[10]Tanzi RE, Kovacs DM, Kim TW, et al. The gene defects responsible for familial Alzheimer' s disease[J]. Neurobiol Dis, 1996,3:159-168.
6[11]Sherrington R, Rogaeve EI, Liang Y, et al. Cloning of a gene bearing missense mutations in early-omset familial Alzheimer' s disease[ J ]. Nature,1995,375:754-760.
7[12]Wragg M, Hutton M, Talbot C, et al. Genetic association between intronic polymorphism in presenilin-1 gene and late-inset Alzheimer' s disease [J]. Lancet, 1996,347:509-512.
8[14]Johansson CB, Momma S, Clarke DL, et al . Identification of a neuzal stem cell in the adult mammalian central nervous system[ J ]. Cell, 1999,96:25-34.
9[15]Doetsch F, Caille I, Lim DA, et al. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain[ J]. Cell, 1999,97:703-716.
10[16]Kaji EH, Leiden JM. Gene and stem cell therapies[ J ]. JAMA,2001,285:545-550.
