舌癌术前单一平阳霉素化疗的临床疗效观察

Retrospective study on the patients with tongue squamous cell carcinoma to Pinyangmycin preoperative chemotherapy

目的 判断平阳霉素对舌鳞状细胞癌的疗效 ,以及适宜的病例 ,减少药物不正当使用。方法 总结十年来接受平阳霉素单一化疗的 5 3个病例 ,计算最低显效剂量 ,分析在不同病理分级、临床分期、生长方式时的效果。结果 单一平阳霉素化疗效果与病理分级、生长方式有相关性 ,与肿瘤大小无相关性 ,部分病例显示出剂量依赖性 ,其疗效与在最低显效剂量下是否敏感有关。结论 对于高分化、外生型舌鳞状细胞癌可选择平阳霉素单一化疗。 5 2 .45± 17.5 3mg可作为平阳霉素化疗的筛选剂量 ,12

Objective To a assess the clinical effects to tongue squamous cell carcinoma with Pinyangmycin before the operation and calculate the minimal effective dose of every case, at which the tumor size was reduced. Methods 53 patients with tongue squamous cell carcinoma have been investigated by comparing the tumor size of prechemotherapy with that of postchemotherapy. Results ① The response of tumor to Pinyangmycin was related to it's degree of differentiation and growth pattern.②It is found that the clinical effect had close relation with the sensibility of the tumor to the minimal effective dose. Conclusion It is suggested the PYM is an efficient drug for well differentiated, exophytic squamous cell carcinoma of tongue. Whether the tumor size reduced at the minimal effective dose may be a predictor of applying PYM to patients with squamous cell carcinoma of tongue. 120 mg of PYM may be considered as a reference dose of preoperative chemotherapy.